SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• 別名: Tyr-Aib-Trp-Phe trifluoroacetate salt
• 実験式（ヒル表記法）: C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• CAS番号: 1334763-90-4
• 分子量: 599.68 (free base basis)
• UNSPSCコード: 12352202
• PubChem Substance ID: 329825306
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: lyophilized solid
• 色: white to beige
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
• InChI Key: NELSAMPJZPTPEG-MDQBHWJISA-N

詳細

生物化学的／生理学的作用

Aib-1 is an inhibitor of β-Amyloid oligomerization.

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable