SMB01068

Licoricidin

≥90% (LC/MS-ELSD)

• 別名: (+)-Licoricidin, 7-O-Demethyllicorisoflavan A, Licorisoflavan B
• 実験式（ヒル表記法）: C₂₆H₃₂O₅
• CAS番号: 30508-27-1
• 分子量: 424.53
• MDL番号: MFCD32182601
• UNSPSCコード: 12352205
• NACRES: NA.25

特性

• 由来生物: plant
• アッセイ: ≥90% (LC/MS-ELSD)
• フォーム: solid
• 分子量: 424.53
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C
• SMILES記法: O1C[C@H](Cc3c1cc(c(c3OC)CC=C(C)C)O)c2c(c(c(cc2)O)CC=C(C)C)O
• InChI: 1S/C26H32O5/c1-15(2)6-8-19-22(27)11-10-18(25(19)29)17-12-21-24(31-14-17)13-23(28)20(26(21)30-5)9-7-16(3)4/h6-7,10-11,13,17,27-29H,8-9,12,14H2,1-5H3/t17-/m0/s1
• InChI Key: GBRZTUJCDFSIHM-KRWDZBQOSA-N

詳細

詳細

Licoricidin, also known as Licorisoflavan B, a hydroxyisoflavan and an aromatic ether, is a bioactive natural compound commonly derived from Glycyrrhiza Sp. (G. uralensis, G. inflata, and G. aspera) plants. Current research indicates that this metabolite is an inhibitor and may possess diverse biological activities, including anti-inflammatory, antitumor, antibacterial, antiangiogenic and antimetastatic properties.

アプリケーション

Licoricidin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生物化学的／生理学的作用

Licoricidin is a potent anti-metastatic agent, effectively reducing the metastatic and invasive capabilities of malignant prostate cancer cells. Additionally, both Licoricidin and Licorisoflavan A exhibit strong antibacterial properties against Porphyromonas gingivalis, Prevotella intermedia, and Solobacterium moorei, with minimal inhibitory concentrations ranging from 2 to 80 µg/ml. These compounds have the potential to mitigate bacterial volatile sulfur compound (VSC) production, making them suitable for managing halitosis. Furthermore, they hold promise for novel approaches to modulate hosts′ responses in conditions involving cytokines and MMPs, such as periodontitis. Licoricidin may find application in topically applied anti-aging formulations by preventing UVA-induced photoaging through ROS scavenging, ultimately limiting MMP-1 activity.

特徴および利点

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable