SAB5700608

Anti-Fas Antibody

rabbit polyclonal

• 別名: ALPS1A, APO-1, APT1, CD95, FAS, FAS1, FASTM, TNFRSF6
• UNSPSCコード: 12352203
• NACRES: NA.43

特性

• product name: Anti-FAS antibody produced in rabbit,
• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 11; 14; 16; 24; 35; 37; 9
• 化学種の反応性: human, rat, mouse
• 濃度: 1.44 mg/ml
• テクニック: immunohistochemistry: 1:50-1:100; western blot: 1:500-1:2000
• UniProtアクセッション番号: P25445
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FAS(355)

詳細

詳細

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FAS (NP_000034.1).

物理的形状

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保管および安定性

Store at -20℃. Avoid freeze / thaw cycles.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable