Anti-SREBP-1 Antibody detects endogenous levels of total SREBP-1 protein.
Sterol regulatory element binding protein-1 (SREBP1) is located on human chromosome 17p11.2. It belongs to the bHLH-Zip transcription factor family. SREBP-1 is a membrane-bound transcription factor liberated by sterol-regulated proteolysis.It is a 125 kD precursor that is bound to the nuclear envelope and endoplasmic reticulum.
免疫原
The antiserum was produced against synthesized peptide derived from human SREBP-1.
Immunogen Range: 405-454
生物化学的/生理学的作用
Sterol regulatory element binding protein-1 (SREBP1) participates in the transcriptional regulation of cellular lipid homeostasis. It controls the hepatic gene expression of lipogenic enzymes and triglyceride deposition in the liver.
特徴および利点
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物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The therapeutic use of statins has been associated to a reduced risk of Parkinson's disease (PD) and may hold neuroprotective potential by counteracting the degeneration of dopaminergic neurons. Transcriptional activation of the sterol regulatory element-binding protein (SREBP) is one of
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11. 2 and 22q13.