SAB5500002

Anti-SMA antibody, Rabbit monoclonal

clone SP171, recombinant, expressed in proprietary host, affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• リコンビナント: expressed in proprietary host
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: SP171, monoclonal
• 化学種の反応性: human (tested)
• 化学種の反応性（ホモロジーによる予測）: rabbit, rat, bovine, chicken, mouse, pig
• テクニック: immunoblotting: 1:50; immunohistochemistry: 1:200
• アイソタイプ: IgG
• UniProtアクセッション番号: P62736
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ACTA2(59)

詳細

詳細

Smooth muscle actin-α (SMA), also known as α2-smooth muscle actin (ACTA2), is a cytoskeleton protein in smooth muscle cells. It is encoded by the gene mapped to human chromosome 10q23.31. SMA is a vascular smooth muscle specific isoform,

Smooth muscle actin-alpha (SMA) is a cytoskeleton protein in smooth muscle cells and their derived tumors such as leiomyoma and leiomyosarcoma. It is also expressed in myoepithelial cells of the breast and salivary gland, but not in fibroblasts, striated muscle, and myocardium.

免疫原

Synthetic peptide near the N-terminus of human SMA protein.

アプリケーション

Anti-SMA antibody, Rabbit monoclonal has been used in:

• western blotting
• immunohistochemistry
• immunofluorescence

生物化学的／生理学的作用

Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and facilitates vascular smooth muscle cell contraction. The encoded protein regulates c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) expression in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Thus, SMA can be used as a potential prognostic biomarker and/or target for treating metastatic lung adenocarcinoma. Mutation in the gene is associated with the development of patent ductus arteriosus (PDA), bicuspid aortic valve (BAV), iris flocculi, livedo reticularis, cerebrovascular accident (CVA) and stenosis of the aortic vasa vasorum. In addition, variation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable