SAB4702027

Monoclonal Anti-Mouse CD45 PerCP produced in mouse

• 別名: GP180, LCA, LY5, T200, TPC
• UNSPSCコード: 12352203

特性

• 結合体: Peridinin-Chlorophyll-Protein Complex conjugate
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: EM-05, monoclonal
• フォーム: buffered aqueous solution
• 交差性: mouse
• 濃度: 0.5 mg/ml
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG
• UniProtアクセッション番号: Q8C6Q7
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... Ptprc(19264)

詳細

詳細

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

特異性

The rat monoclonal antibody EM-05 reacts with an extracellular epitope of murine CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high level on cells of hematopoietic origin, except erythrocytes and platelets.

免疫原

Murine peripheral blood leukocytes

物理的形状

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

調製ノート

Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

保管および安定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

その他情報

The antibody solution should be gently mixed before use.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable