Survivin is also termed as BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5). It is a multifunctional protein. It belongs to the inhibitor of apoptosis protein (IAP) family. BIRC5 is expressed in fetal tissues and several human malignancies like melanoma. Survivin is located on human chromosome 17q25.
免疫原
The antiserum was produced against synthesized peptide derived from human Survivin around the phosphorylation site of Thr34.
Immunogen Range: 11-60
生物化学的/生理学的作用
Survivin/BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5) plays a major role in ATL (adult T-cell leukemia/lymphoma) cell viability. It can block apoptosis and induce the multiplication of cell. BIRC5 also plays a major role in the development of cancer.
特徴および利点
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物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese.
Ma F, et al.
PLoS ONE, 6(2), e16748-e16748 (2011)
Correlation of local and systemic expression of survivin with histopathological parameters of cutaneous melanoma.
Jovic M, et al.
Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review, 73(11), 1022-1029 (2016)
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability.
Pise-Masison CA, et al.
Blood, 113(17), 4016-4026 (2009)
Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy.