SAB4501060

Anti-GAB1 antibody produced in rabbit

affinity isolated antibody

• 別名: GRB2-associated binder 1, GRB2-associated-binding protein 1, growth factor receptor bound protein 2-associated protein 1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 76 kDa
• 交差性: mouse, rat, human
• 濃度: ~1 mg/mL
• テクニック: immunohistochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: Q13480
• UniProtアクセッション番号: Q13480
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GAB1(2549)

詳細

詳細

Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

The GRB2 associated binding protein 1 (GAB1) protein is encoded by the gene mapped to human chromosome 4q31.21. The encoded protein belongs to the Grb2-associated binding protein family. GAB1 protein structure contains pleckstrin homology domain and tyrosine residues. Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human GAB1.

Immunogen Range: 644-674

アプリケーション

Anti-GAB1 antibody produced in rabbit has been used in proximity ligation assay (1:100) and western blotting.[1]

生物化学的／生理学的作用

GRB2 associated binding protein 1 (GAB1) acts as a scaffold protein for protein-protein interaction. It regulates growth factor receptors and enhances signal transduction of multiple intracellular signaling pathways, such as phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT)/ mammalian target of rapamycin (mTOR) signaling pathways. Upregulated expression of GAB1 contributes to the progression of various types of cancer including human oral squamous cell carcinoma (OSCC), breast cancer, colorectal cancer, hepatocellular carcinoma, and ovarian cancer. Therefore, knockdown of the GAB1 gene can be considered as a potential therapeutic strategy for treating breast cancer and OSCC.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable