SAB4200828

Anti-Pseudomonas Exotoxin A-Peroxidase antibody produced in rabbit

IgG fraction of antiserum

• 別名: ETA, NAD(+)--diphthamide ADP-ribosyltransferase, PE
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 結合体: peroxidase conjugate
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 詳細: Research area: Microbiome
• フォーム: lyophilized powder
• 交差性: Pseudomonas aeruginosa
• 濃度: ~4 mg/mL
• テクニック: direct ELISA: 1:10,000-1:20,000 (is recommended using 1 μg/ml Pseudomonas Exotoxin A for coating.)
• UniProtアクセッション番号: P11439
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: Pseudomonas aeruginosa PAO1 ... toxA(877850)

詳細

詳細

Pseudomonas aeruginosa is a Gram negative bacterium that rarely cause diseases in humans but certain populations, such as cystic fibrosis (CF) or burn wounds patients, are prone to such infections.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.

免疫原

Purified Exotoxin A from Pseudomonas aeruginosa

アプリケーション

The antibody may be used in various immunochemical techniques including ELISA.

物理的形状

Supplied as a lyophilized powder.

その他情報

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable