SAB4200671

Anti-S-100 (β-Subunit) antibody, Mouse monoclonal

clone SH-B1, purified from hybridoma cell culture

• 別名: Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse, NEF, S100, S100-B, S100beta
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: mouse
• 品質水準: 200
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: SH-B1, monoclonal
• 交差性: cat, rabbit, porcine, bovine, rat, human
• 濃度: ~1 mg/mL
• テクニック: immunohistochemistry: 1.5-3 μg/mL using immunoperoxidase labeling of pronase digested, formalin-fixed, paraffin-embedded sections of rabbit tongue.
• アイソタイプ: IgG1
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... S100B(6285)

詳細

詳細

Monoclonal Anti-S-100 (β-subunit) (mouse IgG1 isotype) is derived from the SH-B1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. S-100 is a set of small, thermolabile, highly acidic homo or hetero-dimer calcium binding proteins. The protein exists in two isoforms namely, S-100α and S-100β, which are brain specific.

S-100β is a calcium binding protein. It is mainly present in astrocytes and neurons of hindbrain and spinal cord.

免疫原

Purified bovine brain S-100β

アプリケーション

Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse has been used in:

• immunohistochemistry
• enzyme linked immunosorbent assay (ELISA) (Ca²⁺ ion independent)
• immunocytochemistry
• immunoblotting
• dot blot
• immunohistochemistry.

生物化学的／生理学的作用

S-100 is involved in cell-growth regulation, increasing membrane permeability to cations, inflammatory response in many brain diseases, including schizophrenia, stimulation of nucleolar RNA polymerase activity and transporting proteins and free fatty acids in adipocytes. S-100β tissue distribution can be a useful tool in the differential diagnosis of neoplasms and proliferative processes.

S-100β protein interacts with synaptic, cytoskeletal and cell cycle proteins. Additionally, it can regulate calcium levels in glial and neuronal cells. It is involved in neuronal plasticity, astrogliosis and neuronal cell survival. S-100β is associated with Alzheimer disease and amyotrophic lateral sclerosis.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable