由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
分子量
antigen ~160 kDa
交差性
human
強化検証
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
テクニック
western blot: 1.5-3.0 μg/mL using HEK-293T cells over expressing human tensin 2.
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TENC1(23371)
詳細
Tensin 2 belongs to the Tensin family. It shares extensive homology with tensin1 at its N- and C-terminals, including the actin-binding domain, the Src Homology 2 (SH2) and c domains. Tensin 2 mRNA is highly expressed in heart, kidney, skeletal muscle and liver.
免疫原
synthetic peptide corresponding to a sequence located near the C-terminus human tensin 2 (GeneID: 23371), conjugated to KLH. The corresponding sequence is identical in human tensin 2 isoforms 2 and 3, and highly conserved (single amino acid substitution) in mouse tensin 2.
アプリケーション
Anti-Tensin 2 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
生物化学的／生理学的作用
Tensin 2 interacts with several binding partners through its Src Homology 2 (SH2)-phosphotyrosine binding (PTB) domains, including Axl receptor tyrosine kinase (RTK), caveolin-1 and with the tumor suppressor gene deleted in liver cancer 1 (DLC1) to regulate DLC1 tumor suppressor activity. Tensin 2 also inhibits Akt signaling and cell survival. It reduces intracellular PtdIns(3,4,5)P3 levels at the plasma membrane. It modulates cytoskeletal dynamics and impacts phosphoinositide-Akt signaling through its PTPase domain. Tensin 2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma (HCC).
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200268-VAR:
IXO14934:
SAB4200268-200UL:
SAB4200268-BULK:
SAB4200268-25UL:
最新バージョンのいずれかを選択してください：
AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells
Cheng LC, et al.
Journal of Biomedical Science, 25(1), 80-80 (2018)
Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing
Marusugi K, et al.
The Journal of Veterinary Medical Science, 78(9), 1413-1420 (2016)
Kiyoma Marusugi et al.
The Journal of veterinary medical science, 78(9), 1413-1420 (2016-06-02)
Podocytes are terminally differentiated and highly specialized cells in the glomerulus, and they form a crucial component of the glomerular filtration barrier. The ICGN mouse is a model of glomerular dysfunction that shows gross morphological changes in the podocyte foot
Tensin2 reduces intracellular phosphatidylinositol 3, 4, 5-trisphosphate levels at the plasma membrane
Hafizi S, et al.
Biochemical and Biophysical Research Communications, 399(3), 396-401 (2010)
Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function
Chan LK, et al.
PLoS ONE, 4(5), e5572-e5572 (2009)
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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