SAB4200263

Anti-PLEKHA7 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: Anti-Pleckstrin homology domain-containing family A member 7
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~130 kDa
• 交差性: human
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 2.5-5 μg using lysates of HEK- 293T cells overexpressing human PLEKHA7; indirect immunofluorescence: 1.0-2.0 μg/mL using Caco2 cells; western blot: 0.5-1 μg/mL using lysates of HEK- 293T cells overexpressing human PLEKHA7
• UniProtアクセッション番号: Q6IQ23
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PLEKHA7(144100)

詳細

詳細

The Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) gene is located on the human chromosome 11p15.2-p15.1. The encoded protein is compsed of WW, pleckstrin homology (PH) and coiled-coil (CC) domains. It is a part of cadherin-based protein complex in mammalian epithelial cells.

特異性

Anti-PLEKHA7 (N-terminal) recognizes human PLEKHA7.

免疫原

synthetic peptide corresponding to the N- terminal region of human PLEKHA7, conjugated to KLH. The corresponding sequence differs by two amino acids in mouse.

アプリケーション

Anti-PLEKHA7 (N-terminal) antibody produced in rabbit is suitable for:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生物化学的／生理学的作用

Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) protein is involved in the cadherin-based protein complex mediated anchoring of microtubule minus ends to the zonula adherens (ZA). This process is neccessary for the biogenesis of specialized junction. PLEKHA7 forms complexes with E-cadherin and cadherin associated protein p120-catenin complexes. It significantly aids in the translocation of NEZHA to the ZA.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable