由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~115 kDa
交差性
human
包装
antibody small pack of 25 μL
強化検証
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
テクニック
western blot: 2-4 μg/mL using HS68 cell extracts
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... NEDD9(4739)
詳細
Neural precursor cell expressed developmentally down-regulated protein 9 (Nedd9), also known as CRK-associated substrate-related protein (Cas-L) and human enhancer of filamentation 1 (HEF1), is an adhesion adapter protein. Nedd9 gene is mapped to human chromosome 6p24.2. It belongs to a larger family of Cas docking adapter proteins and is expressed preferentially in lymphocytes and epithelial cells.
特異性
Anti-Nedd9 specifically recognizes human Nedd9.
アプリケーション
Anti-Nedd9 antibody produced in rabbit may be used in immunoblotting.
生物化学的／生理学的作用
Neural precursor cell expressed developmentally down-regulated protein 9 (Nedd9) participates in integrin and growth factor signaling pathways that regulate growth, motility and apoptosis. It is thought to play an important role in early neuronal differentiation and brain development. Nedd9 undergoes extensive phosphorylation, a process dependent both on cell adhesion and on the integrity of the actin cytoskeleton. Focal adhesion kinase (FAK) and sarcoma (Src) regulate Nedd9. Nedd9 is implicated in metastatic cancer and is upregulated in solid tumors and ovarian cancer. Overexpression of Nedd9 is implicated in the invasion of glioblastoma and in the pathogenesis of breakpoint cluster region-Abelson (Bcr-Abl)-dependent tumor .
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200212-VAR:
SAB4200212-25UL:
IXO14885:
SAB4200212-BULK:
SAB4200212-200UL:
最新バージョンのいずれかを選択してください：
Hua-Xin Duan et al.
American journal of physiology. Gastrointestinal and liver physiology, 316(6), G763-G773 (2019-03-29)
Tumor-associated angiogenesis plays a critical role in the pathogenesis of cholangiocarcinoma (CCA). In this study, we examined the biological effects and molecular mechanisms of transcription factor 21 (TCF21) on CCA-associated angiogenesis. TCF21 expression was compared between 15 pairs of peritumor
Roles of neural precursor cell expressed, developmentally downregulated 9 in tumor-associated cellular processes
Zhang S and Wu L
Molecular Medicine Reports, 12(5), 6415-6421 (2015)
Christian Dölle et al.
Scientific reports, 8(1), 1272-1272 (2018-01-21)
3,3'-Diaminobenzidine (DAB) is a widely used chromogen in histological staining methods and stained tissue is often used in downstream molecular analyses such as quantitative PCR (qPCR). Using microdissected muscle fibers from sequential muscle sections stained by DAB-dependent and -independent methods
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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