SAB3500544

Anti-NOD3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-CLR16.2, Anti-NLRC3, Anti-Nucleotide-binding oligomerization domain containing 3
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: rat, mouse, human
• テクニック: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBIアクセッション番号: EAW85351
• UniProtアクセッション番号: Q7RTR2
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NLRC3(197358)

詳細

詳細

NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.

免疫原

NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.

生物化学的／生理学的作用

NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.

特徴および利点

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関連事項

The action of this antibody can be blocked using blocking peptide SBP3500544.

物理的形状

PBS（0.02％ アジ化ナトリウム含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable