Slc22A17 gene is also referred to as brain organic cation transporter (BOCT) and is mapped to human chromosome 14q11.2. The encoded protein is predominantly localized to kidney and liver. The Slc22 proteins consists of 12 transmembrane (TM) α-helices with an extended loop (extracellular) between the first and the second transmembrane regions, and a loop (intracellular) between the sixth and the seventh transmembrane regions.
免疫原
Slc22A17 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human Slc22A17.
生物化学的/生理学的作用
Slc22A17 expression is associated with important biological processes such as cell differentiation, apoptosis and inflammation. Slc22A17 mediates endocytosis of neutrophil gelatinase-associated lipocalin, a mammalian protein that can bind to bacterial siderophore enterobactin with high affinity.
特徴および利点
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関連事項
The action of this antibody can be blocked using blocking peptide SBP3500306.
物理的形状
PBS(0.02% アジ化ナトリウム含有)
免責事項
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Biochemical and structural characterization of the interaction between the Siderocalin NGAL/LCN2 and the N-terminal domain of its endocytic receptor SLC22A17.
The solute carrier family 22 (SLC22) is a large family of organic cation and anion transporters. These are transmembrane proteins expressed predominantly in kidneys and liver and mediate the uptake and excretion of environmental toxins, endogenous substances, and drugs from
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.