SAB3500113

Anti-FRMPD1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-FERM and PDZ domain-containing 1, Anti-FRMD2
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: human
• テクニック: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBIアクセッション番号: NP_055722
• UniProtアクセッション番号: Q5SYB0
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FRMPD1(22844)

詳細

免疫原

FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

ターゲットの説明

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.

関連事項

The action of this antibody can be blocked using blocking peptide SBP3500113.

物理的形状

約1 mg/mLのPBS (0.02％ アジ化ナトリウム含有)

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable