SAB3500112

Anti-MIMITIN antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-Assembly factor 2, Anti-MMTN, Anti-NADH dehydroxygenase (ubiquinone) 1 alpha subcomplex, Anti-NDUFA12L, Anti-NDUFAF2
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: human
• テクニック: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBIアクセッション番号: NP_777549
• UniProtアクセッション番号: Q8N183
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NDUFAF2(91942)

詳細

免疫原

Mimitin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Mimitin.

特徴および利点

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ターゲットの説明

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

関連事項

The action of this antibody can be blocked using blocking peptide SBP3500112.

物理的形状

約1 mg/mLのPBS (0.02％ アジ化ナトリウム含有)

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable