Natriuretic peptide receptor 3 (NPR3) is a natriuretic peptide receptor. It is expressed in endothelial cells, vessels, endocrine glands, lungs and kidneys. The gene encoding NPR3 is localized on human chromosome 5p14-p13. The protein consists of a 450-amino acid extracellular ligand-binding domain, a transmembrane region and a cytoplasmic tail.
免疫原
Peptide with sequence C-HRELREDSIRSHFS, from the C-terminal region of the protein sequence according toNP_000899.1
アプリケーション
Anti-NPR3 (C-terminal) antibody produced in goat has been used in Western blotting.
生物化学的/生理学的作用
Natriuretic peptide receptor 3 (NPR3) has a role in the clearance of natriuretic peptides and modulates their plasma levels. It is associated with essential hypertension. NPR3 may be involved in signaling pathways and is associated with inhibitory G protein.
特徴および利点
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Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo. Here, we show that acute cold exposure induces cardiac ANP secretion in mice and humans.
NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study.
Hu Q
Oncotarget (2016)
Attenuated atrial natriuretic peptide-mediated
lipolysis in subcutaneous adipocytes of obese
type 2 diabetic men
Kenneth Verboven
Clinical Science (2016)
Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
Pereira NL
Circulation. Cardiovascular Genetics (2013)
Association of NPRA and NPRC gene variants and hypertension in Mongolian population.