Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is a sequence-specific binding protein that belongs to the CPEB family. It consists of two domains, an unstructured domain, and a RNA binding domain. CPEB4 is expressed in the spinal cord and brain. The CPEB4 gene is mapped on the human chromosome at 5q35.2.
免疫原
Synthetic peptide directed towards the N terminal region of human CPEB4
生物化学的/生理学的作用
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) plays a key role in translational control during tumor development and modulates various biological processes in tumor progression, including invasion, metastasis, tumor cell growth, and vascularization. It is involved in pathologic angiogenesis, terminal erythroid differentiation, and non-neuronal tissues for cancer progression. Overexpression of the CPEB4 gene is associated with pancreatic ductal adenocarcinoma and glioblastoma.
シーケンス
Synthetic peptide located within the following region: DEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGD
物理的形状
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
CPEB4 is an RNA binding protein expressed in neuronal tissues including brain and spinal cord. CPEB4 has two domains: one that is structured for RNA binding and one that is unstructured and low complexity that has no known function. Unstructured
CPEB4 plays an important role in cancer progression. However, the clinicopathological significance of CPEB4 expression to glioma and its expression levels in glioma tissues and cell lines are unknown. The present study investigated the potential prognostic value of CPEB4 for