SAB1410861

Anti-OPRL1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 別名: KOR-3, MGC34578, NOCIR, OOR, ORL1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 40.7 kDa
• 交差性: human
• テクニック: western blot: 1 μg/mL
• NCBIアクセッション番号: NM_000913
• UniProtアクセッション番号: P41146
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... OPRL1(4987)

詳細

詳細

Opioid related nociceptin receptor 1 (OPRL1) is mapped to human chromosome 20q13.33. The gene codes for the nociceptin/orphanin FQ receptor (NOP-R), which is a G protein-coupled receptor expressed at various levels all over the brain and spinal cord. OPRL1 belongs to the opioid receptor family.

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)

免疫原

OPRL1 (NP_000904.1, 1 a.a. ~ 370 a.a) full-length human protein.

Sequence
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA

生物化学的／生理学的作用

Opioid related nociceptin receptor 1 (OPRL1) plays a vital role in alcohol and other drug reward pathways. The encoded protein is involved in regulating tolerance and behavioral responses to morphine. Phosphorylation of NOPR at serine 363 by G protein-coupled receptor kinase 3 (GRK3) facilitates arrestin-dependent Jun amino-terminal kinases (JNK) mitogen-activated protein kinase (MAPK) signaling. Mutation in the gene is associated with the risk to develop opiate addiction.

物理的形状

無色透明のPBS溶液、pH 7.4

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable