SAB1407028

Anti-ARID3B antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• 別名: BDP, DRIL2
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~27.8 kDa
• 交差性: human
• テクニック: indirect immunofluorescence: suitable; western blot: 1 μg/mL
• NCBIアクセッション番号: BC060824
• UniProtアクセッション番号: Q8IVW6
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ARID3B(10620)

詳細

詳細

AT-rich interaction domain 3B (ARID3B) is encoded by the gene mapped to human chromosome 15q24.1. It is mainly expressed in leukocytes, placenta and testis. ARID3B belongs to the AT-rich interaction domain (ARID) family of proteins.

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. (provided by RefSeq)

免疫原

ARID3B (AAH60824.1, 1 a.a. ~ 253 a.a) full-length human protein.

Sequence
MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQKLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDEDGDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFVFMQKRGECASTHHSNSGNTDRVPTVC

生物化学的／生理学的作用

AT-rich interaction domain 3B (ARID3B) plays a vital role in the survival of neural crest during embryogenesis. It is involved in the pathogenesis of malignant neuroblastoma. ARID3B also facilitates the expression of pro-apoptotic p53-target genes and apoptosis.

物理的形状

無色透明のPBS溶液、pH 7.4

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable