SAB1304990

ANTI-DNASE1L3 (N-TERM) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 別名: DHP2, DNAS1L3, DNASE1L3, Deoxyribonuclease gamma
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: 35504 Da
• 交差性: human
• テクニック: western blot: 1:1000
• NCBIアクセッション番号: NP_004935.1
• UniProtアクセッション番号: Q13609
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DNASE1L3(1776)

詳細

詳細

DNASE1L3 (Deoxyribonuclease I-like 3) is a 32kDa endonuclease protein expressed in the spleen, liver, thymus, lymph node, bone marrow, small intestine and kidney. It consists of an N-terminal signal peptide responsible for the rER (rough endoplasmic reticulum) transport.

アプリケーション

ANTI-DNASE1L3 (N-TERM) antibody produced in rabbit is suitable for western blot assay at a dilution of 1:250-1:500.

生物化学的／生理学的作用

DNASE1L3 (Deoxyribonuclease I-like 3) is involved in residual nuclease activity of internucleosomal chromatin. In presence of Ca²⁺/Mg²⁺, it produces 3′-OH/5′-P ends by cleaving both the DNA strand, double-stranded and single-stranded DNA molecule. It has also been reported that DNASE1L3 may cleave apoptotic DNA of thymocytes, neuronal PC12 cells, C2C12 myoblasts and of cell lines expressing the recombinant nuclease. Mutation in DNASE1L3 causes a rare syndrome, hypocomplementemic urticarial vasculitis syndrome (HUVS).

物理的形状

精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）この抗体は、プロテインAカラムろ過後にペプチドアフィニティカラムで精製されます。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable