SAB1301592

ANTI-DIO3 (C-TERM) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 別名: 5DIII, DIO3, DIOIII, ITDI3, TXDI3, Type 3 DI, Type III iodothyronine deiodinase, Type-III 5′-deiodinase
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: 31451 Da
• 交差性: human
• テクニック: immunohistochemistry: 1:50-1:100; western blot: 1:250-1:500
• NCBIアクセッション番号: NP_001353
• UniProtアクセッション番号: P55073
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DIO3(1735)

詳細

詳細

Iodothyronine deiodinase 3 (DIO3) is highly expressed in central nervous system, fetal liver and placenta. DIO3 is a selenoenzyme with insertion sequence element containing selenocysteine in the 3′UTR (untranslated region). In human chromosome, the gene DIO3 is localized on 14q32.31.

生物化学的／生理学的作用

Iodothyronine deiodinase 3 (DIO3) regulates the serum level of thyroid hormone. DIO3 removes iodine from the inner ring of T4 (thyroxine) and T3 (triiodothyronine) and converts to its inactive forms. The major role of DIO3 is to protect exposure of fetal tissues to high level of T3 throughout gestation. Elevated expression of DIO3 is associated with infantile hepatic hemangiomas (IHH). Alterations in the thyroid hormone exposure during developmental stages may cause phenotypes similar to uniparental disomy of chromosome 14. The lack of DIO3 leads to neonatal thyrotoxicosis, followed by hypothyroidism. DIO3 is crucial for auditory development. Mutations in DIO3 leads to deafness due to immature cochlear differentiation. DIO3 protects the immature cones by regulating the hormonal exposure, facilitating cone survival and opsins patterning.

物理的形状

精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）この抗体は、プロテインAカラムろ過後にペプチドアフィニティカラムで精製されます。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable