由来生物
rabbit
結合体
unconjugated
抗体製品の状態
saturated ammonium sulfate (SAS) precipitated
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human
テクニック
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PARG(8505)
詳細
PARG (Poly ADP-ribose glycohydrolase) is a catabolic enzyme with molecular mass ranging from 60-74kDa. It has four isoforms namely G1, G2, G3 and G4 with high protease sensitivity.
免疫原
PARG (NP_003622, 329-364)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Parg.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human Parg.
アプリケーション
Anti-PARG (N-term) antibody produced in rabbit is suitable for indirect ELISA (1:1000) and immunohistochemistry (1:50-1:100) applications.
生物化学的／生理学的作用
PARG (Poly ADP-ribose glycohydrolase) is involved in several gene regulation processes such as maintenance of chromatin structure, transcription, DNA repair and apoptosis. It regulates retinoic acid receptor (RAR)-mediated transcription during chromatin remodeling. It catabolically separate ADP-ribose polymers synthesized by poly-(ADP-ribose) polymerases. A study shows that PARG plays a therapeutic role in various physiological conditions such as inflammation, ischemia, stroke, and cancer chemotherapy.
物理的形状
精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Wookee Min et al.
Frontiers in bioscience (Landmark edition), 14, 1619-1626 (2009-03-11)
Poly (ADP-robose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes. The growing evidence supports the importance of a tight control of poly (ADP-ribose) metabolism by the
Nicolas Le May et al.
Molecular cell, 48(5), 785-798 (2012-10-30)
Poly-(ADP-ribose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers synthesized by poly-(ADP-ribose) polymerases. Here, transcriptome profiling and differentiation assay revealed a requirement of PARG for retinoic acid receptor (RAR)-mediated transcription. Mechanistically, PARG accumulates early at promoters of RAR-responsive
M-E Bonicalzi et al.
Cellular and molecular life sciences : CMLS, 62(7-8), 739-750 (2005-05-04)
Poly(ADP-ribose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers formed by members of the PARP family of enzymes. Despite its discovery and subsequent partial purification in the 1970s and the cloning of its single gene in the late
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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