S0826

S-PMH

≥98% (HPLC)

• 別名: (Z)-5-(4-(エチルチオ)ベンジリデン)-ヒダントイン, (Z)-5-[4-(エチルチオ)ベンジリデン]イミダゾリジン-2,4-ジオン, 5-(4-エチルスルファニルベンジリデン)イミダゾリジン-2,4-ジオン
• 実験式（ヒル表記法）: C₁₂H₁₂N₂O₂S
• CAS番号: 1134426-32-6
• 分子量: 248.30
• MDL番号: MFCD12912441
• UNSPSCコード: 12352202
• PubChem Substance ID: 329824180

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: yellow
• 溶解性: DMSO: >20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CCSc1ccc(cc1)\C=C2/NC(=O)NC2=O
• InChI: 1S/C12H12N2O2S/c1-2-17-9-5-3-8(4-6-9)7-10-11(15)14-12(16)13-10/h3-7H,2H2,1H3,(H2,13,14,15,16)/b10-7-
• InChI Key: UWMDBDYLNJITCD-YFHOEESVSA-N

詳細

生物化学的／生理学的作用

S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes.

S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.

特徴および利点

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable