R2030

抗RACK1 (C末端) 抗体 ウサギ宿主抗体

~1 mg/mL, affinity isolated antibody, buffered aqueous solution, immunoprecipitation: 5 μg

• 別名: 抗GNB2L1抗体, 抗Gnb2-rs1抗体, 抗H12.3抗体, 抗HLC-7抗体, 抗PIG21抗体, 抗グアニンヌクレオチド結合タンパク質 (Gタンパク質), ベータポリペプチド2様1抗体, 抗ニワトリB複合体タンパク質相同タンパク質 (protein homologous to chicken B complex protein) 抗体, 抗増殖誘導遺伝子21抗体, 抗活性型プロテインキナーゼC1レセプター抗体, 抗肺がん癌遺伝子7抗体
• MDL番号: MFCD01634078
• UNSPSCコード: 12352203
• NACRES: NA.44

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~30 kDa
• 交差性: rat, human, mouse
• 濃度: ~1 mg/mL
• テクニック: immunoprecipitation (IP): 5-10 μg; western blot: 0.5-1 μg/mL using HEK-293T cell
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GNB2L1(10399) ; mouse ... Gnb2l1(14694) ; rat ... Gnb2l1(83427)

詳細

詳細

Receptors for activated C-kinase (RACKs) are scaffold proteins for protein kinase C (PKC). It is composed of seven WD repeats, thus resembling the structure of the β subunit of G proteins. It is not a substrate of PKC, but in its presence, the activity of PKC is increased by several fold.

免疫原

ヒトRACK1のアミノ酸268~282に相当する合成ペプチド (N末端システイン付加) のKLH結合体。相当する配列はヒト、ラット、マウスで保存されています。

生物化学的／生理学的作用

RACK1 is a receptor for activated C kinases that functions downstream of the growth factor receptor signaling pathway. RACK1 also modulates several functions such as cell adhesion, chemotaxis and protrusion. Increased RACK1 expression has been associated with cell migration and metastasis in breast carcinoma. Thus, RACK1 can be used as a prognostic indicator for breast cancer

Receptors for activated C-kinase (RACKs) anchor activated protein kinase C (PKC) at the site of translocation. RACK1 is the selective RACK for PKCβII. In addition to anchoring activated PKC, RACK1 anchors other signaling enzymes such as sarcoma Src tyrosine kinase, integrin and phosphodiesterase 4D5. The ability of RACK1 to interact simultaneously with different signaling molecules, allows it to integrate inputs from distinct signaling pathways. In mammals, it regulates several processes that involve contact with extracellular matrix such as spreading, the establishment of focal adhesions and cell-cell contacts. Accumulating evidence attributes to it the role of regulating several major nervous system pathways. In addition, RACK1 is a ribosomal protein and a component small subunit and interacts ribosomal RNA. It recruits activated PKC to the ribosome, which in turn, phosphorylates initiation factor 6, leading to ribosome assembly.

物理的形状

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)