Q4972

QS11 水和物

≥98% (HPLC), powder

• 別名: (2S)-2-[2-(インダン-5-イルオキシ)-9-(1,1'-ビフェニル-4-イル)メチル)-9H-プリン-6-イルアミノ]-3-フェニル-プロパン-1-オール水和物
• 実験式（ヒル表記法）: C₃₆H₃₃N₅O₂ · xH₂O
• CAS番号: 944328-88-5
• 分子量: 567.68 (anhydrous basis)
• MDL番号: MFCD12912439
• UNSPSCコード: 12352203

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white
• 溶解性: DMSO: >10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O.OC[C@H](Cc1ccccc1)Nc2nc(Oc3ccc4CCCc4c3)nc5n(Cc6ccc(cc6)-c7ccccc7)cnc25

詳細

生物化学的／生理学的作用

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway.

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)