PLA0079
Rabbit anti-PCNA Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
別名:
ATLD2, DNA polymerase delta auxiliary protein, PCNA, cyclin
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100 μL
￥73,700
￥73,700
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品質そのまま、お求めになりやすい価格になりました。メルクは皆さんの科学発展を支えるパートナーとして製品を提供します。
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100 μL
￥73,700
About This Item
UNSPSCコード:
12352203
NACRES:
NA.41
￥73,700
Check Cart for Availability
品質そのまま、お求めになりやすい価格になりました。メルクは皆さんの科学発展を支えるパートナーとして製品を提供します。
おすすめの製品
由来生物
rabbit
品質水準
抗体製品の状態
affinity purified immunoglobulin
抗体製品タイプ
primary antibodies
交差性
human, mouse
テクニック
flow cytometry: 0.03 μg
immunohistochemistry: 1:2,000- 1:10,000
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:1,000- 1:10,000
アクセッション番号
P12004
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
rabbit ... PCNA(5111)
関連するカテゴリー
1 of 4
当該品目 | PLA0080 | PLA0270 | PLA0072 |
|---|---|---|---|
| species reactivity human, mouse | species reactivity mouse, human | species reactivity human | species reactivity human |
| antibody form affinity purified immunoglobulin | antibody form affinity purified immunoglobulin | antibody form affinity purified immunoglobulin | antibody form affinity purified immunoglobulin |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| Gene Information rabbit ... PCNA(5111) | Gene Information rabbit ... PCNA(5111) | Gene Information rabbit ... PolA1(5422) | Gene Information rabbit ... p53(7157) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
詳細
Proliferating cell nuclear antigen (PCNA), a single-copy gene, spans about 12 kb. This gene is located on human chromosome 20p13. PCNA is expressed at high levels in the thymus, bone marrow, fetal liver, and some cells of the small intestine and colon. It is located in the nucleus.
免疫原
The epitope recognized by PLA0079 maps to a region between residues 75 and 125 of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
アプリケーション
Rabbit anti-PCNA Antibody, Affinity Purified has been used in:
- proximity ligation assay (PLA) (1:500)[1]
- immunoblotting (1:2000)
- flow cytometry analysis
生物化学的／生理学的作用
Proliferating cell nuclear antigen (PCNA) protein functions as an auxiliary factor of polymerase δ. It acts as a cofactor to polymerase ε, polymerase β, and translesion synthesis polymerases, such as η, κ, λ, and θ. In chronic lymphoid leukemia (CLL) patients, intracellular levels of PCNA protein can be used as a marker to identify clinical behavior and survival.
物理的形状
トリスクエン酸／リン酸塩緩衝液、pH 7～8、0.09％ アジ化ナトリウム含有
その他情報
PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
PLA0079-100UL-KC:
PLA0079-100UL:
最新バージョンのいずれかを選択してください：
Qun Wang et al.
Heart, lung & circulation, 25(11), 1124-1132 (2016-05-18)
Coronary artery bypass grafting is employed for the treatment of multiple-vessel lesions. Studies have shown that continued maladaptive remodelling expedites atherosclerosis and that excessive remodelling leads to graft restenosis. However, few studies have focussed on mechanistic target of rapamycin (mTOR)
PCNA on the crossroad of cancer
Stoimenov I, Helleday T
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
James P Wells et al.
PLoS genetics, 18(12), e1010309-e1010309 (2022-12-09)
DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as well as oncogenic stress, can challenge replication by fostering conflicts with transcription and stabilizing DNA:RNA hybrids. RAD18 is an E3 ubiquitin ligase for PCNA that is involved
Qiyuan Zhou et al.
American journal of respiratory cell and molecular biology, 54(5), 728-739 (2015-10-22)
We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in
Emily Yun-Chia Chang et al.
Nature communications, 10(1), 4265-4265 (2019-09-21)
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-loop mechanisms, we performed a genome-wide trigenic
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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