P3371

ペンフルリドール

≥97% (HPLC), powder

• 別名: 1-[4,4-ビス(4-フルオロフェニル)ブチル]-4-[4-クロロ-3(トリフルオロメチル)フェニル]-4-ピペリジノール, R16341
• 実験式（ヒル表記法）: C₂₈H₂₇ClF₅NO
• CAS番号: 26864-56-2
• 分子量: 523.97
• EC Number: 248-074-5
• MDL番号: MFCD00866714
• UNSPSCコード: 12352200
• PubChem Substance ID: 329820171
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• フォーム: powder
• 色: white
• 溶解性: DMSO: >20 mg/mL; H₂O: insoluble
• オーガナイザー: Johnson & Johnson
• 保管温度: 2-8°C
• SMILES記法: OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F
• InChI: 1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2
• InChI Key: MDLAAYDRRZXJIF-UHFFFAOYSA-N

詳細

アプリケーション

Penfluridol has been used as an antipsychotic agent:

• to study its antimetastatic effect on triple-negative breast cancer cells[1]
• to study its effects on the growth of glioblastoma cell lines[1],
• to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)[2]

生物化学的／生理学的作用

T型Ca²⁺ チャネルブロッカ-で、統合失調症治療薬です。

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis.[2] It also exhibits anticancer activity.[1]

特徴および利点

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges