O1016

OPC-21268 hydrate

≥98% (HPLC)

• 別名: 1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate
• 実験式（ヒル表記法）: C₂₆H₃₁N₃O₄ · xH₂O
• CAS番号: 131631-89-5
• 分子量: 449.54 (anhydrous basis)
• MDL番号: MFCD18632552
• UNSPSCコード: 51111800
• PubChem Substance ID: 329818893
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to off-white
• 溶解性: DMSO: ≥20 mg/mL
• オーガナイザー: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 保管温度: 2-8°C
• SMILES記法: O.CC(=O)NCCCOc1ccc(cc1)C(=O)N2CCC(CC2)N3C(=O)CCc4ccccc34
• InChI: 1S/C26H31N3O4.H2O/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31;/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30);1H2
• InChI Key: QTCWOUIERWBMQV-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

OPC-21268 is one of 2 non-peptide V1a selective antagonists, along with SR-49059. Arginine vasopressin (AVP) is a hormone that plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). There are three AVP receptor subtypes-V1a, V1b, and V2 - all belong to the large rhodopsin-like G-protein-coupled receptor family. V(1a) antagonists improve water balance and cardiac hypertrophy in CHF and might be beneficial for the treatment of water retention and cardiac remodeling in CHF.

特徴および利点

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H400
• 注意書き: P273 - P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable