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由来生物
human liver (hepatocytes)
フォーム
liquid
使用法
sufficient for 1 96-well plate(s) (or 24-well plate)
包装
vial of ≥5 mil. cells
メーカー／製品名
LifeNet Health®
成長モード
adherent
詳細
≥70%, confluent monolayer up to day 4
テクニック
cell culture | mammalian: suitable
drug transporter assay: suitable
genotyping: suitable
アプリケーション
ADME/TOX
関連疾患
non-alcoholic steatohepatitis (NASH); non-alcoholic/simple fatty liver (NAFL)
輸送温度
liquid nitrogen
保管温度
−196°C
詳細
We provide high viability cryoplatable hepatocytes, sourced from LifeNet Health® that predictably represents in vivo conditions. Applications for primary hepatocytes include in vitro evaluation of metabolism, drug-drug interaction, drug transporter activity, and toxicity of drug candidates. There are many other applications that encompass cryoplatable hepatocytes.
アプリケーション
See technical bulletins for detailed protocols.
Click lot availability link to get a complete list of currently available hepatocyte lots from LifeNet Health®.
Once the lot number(s) of interest are determined enter the lot number into the “Certificate of Analysis” request search engine at the bottom of the page to obtain a pdf copy of the CoA. Note, lot number CoA upload is only available on the product number detail page corresponding with the lot number.
Click lot availability link to get a complete list of currently available hepatocyte lots from LifeNet Health®.
Once the lot number(s) of interest are determined enter the lot number into the “Certificate of Analysis” request search engine at the bottom of the page to obtain a pdf copy of the CoA. Note, lot number CoA upload is only available on the product number detail page corresponding with the lot number.
特徴および利点
These cryoplatable hepatocytes are sourced from LifeNet Health®. All cryoplatable hepatocytes have post-thaw viabilities over 80%. These lots are also characterized for Phase I CYP450 isoform and Phase II drug-metabolizing enzyme activity. Cryoplatable hepatocytes can be used for a variety of applications including metabolic stability, clearance, metabolite ID, metabolite profiling, species comparison studies, and uptake transporter studies.
Each lot is fully characterized for viability/stability, cell yield, attachment efficiency, optimal seeding density, monolayer confluency, Phase I and Phase II drug metabolizing enzyme activities and cyp induction. We have a wide selection of lots that can be used for a variety of applications, including, but not limited to:
Each lot is fully characterized for viability/stability, cell yield, attachment efficiency, optimal seeding density, monolayer confluency, Phase I and Phase II drug metabolizing enzyme activities and cyp induction. We have a wide selection of lots that can be used for a variety of applications, including, but not limited to:
- Drug metabolizing enzyme activity (stability, clearance, metabolite profiling and ID)
- Time-dependent metabolism (plated assay for low-clearance compounds)
- CYP450 Induction (mRNA and activity)
- Plated drug transporter assays (uptake and efflux)
- Toxicity assays
- High content analysis
- High content imaging
- 3D culture
包装
This product will be shipped in a liquid nitrogen dry shipper supplied from Cryoport. Please remember to ship the container back to Cryoport once you have removed the materials. Additional Cryoport shipping charges may apply.
Please see the Cryoport website for more details on the dry shipper.
Please see the Cryoport website for more details on the dry shipper.
法的情報
LifeNet Health is a registered trademark of LifeNet Health
必要ですが提供されていません
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MTOXH1001-1VL:
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）