MSST0015

SILu^™Prot B2M beta-2-microglobulin human

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, ¹³C- and ¹⁵N-labeled

• 別名: β-2-microglobulin
• UNSPSCコード: 23201100
• NACRES: NA.12

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in HEK 293 cells
• アッセイ: ≥98% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: ≥98% Heavy amino acids incorporation efficiency by MS
• テクニック: mass spectrometry (MS): suitable
• 適合性: suitable for mass spectrometry (standard)
• UniProtアクセッション番号: P61769
• 保管温度: −20°C
• 遺伝子情報: human ... B2M(567)

詳細

詳細

SILu^™ Prot B2M is a recombinant, stable isotope-labeled human B2M which incorporates [¹³C₆, ¹⁵N₄]-Arginine and [¹³C₆, ¹⁵N₂]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of B2M in mass-spectrometry. SILu^™ Prot B2M is a monomer of 119 amino acids (including C-terminal polyhistidine and flag tags), with a molecular weight of ~14 kDa.
Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)

生物化学的／生理学的作用

B2M is the light chain of the major histocompatibility class (MHC) I molecule expressed on the cell surface of all nucleated cells. Increased urinary B2M excretion has been observed to be an early marker of tubular injury in a number of settings, including nephrotoxicant exposure, cardiac surgery, and renal transplantation, preceding rises in serum creatinine by as many as 4−5 days. B2M may also serve as an early biomarker for AKI (Acute Kidney Injury).

シーケンス

IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMDYKDDDDKGHHHHHHHHGGQ

物理的形状

Supplied as a lyophilized powder containing phosphate buffered saline.

法的情報

SILu is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable