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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 80-85 kDa
化学種の反応性
human, mouse, rat
包装
antibody small pack of 25 μL
濃度
~1 mg/mL
テクニック
immunoprecipitation (IP): 5-10 μg using Jurkat cell lysates
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MLH1(4292)
mouse ... Mlh1(17350)
rat ... Mlh1(81685)
詳細
MLH1 is part of a large multi-subunit protein complex of tumor suppressors, DNA damage sensors, and signal transducers, named BRCA1-associated genome surveillance complex (BASC).
MutL homolog 1 (MLH1) is a nucleoprotein and a major component of mismatch repair system. The MLH1 gene is located in chromosome 3p21 and is made up of 19 exons. The protein has a molecular weight of 80kDa.
特異性
Anti-MLH1 (C-terminal) specifically recognizes human MLH1 (80-85 kDa).
免疫原
ヒトMLH1のアミノ酸591~606に相当する合成ペプチド (N末端システイン付加) のKLH結合体。相当するペプチド配列はヒト、ラット、マウスで保存されています。
アプリケーション
Anti-MLH1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation
生物化学的／生理学的作用
A hereditary mutation in the MLH1 gene is implicated in nonpolyposis colorectal cancer-2.
MutL homolog 1 (MLH1) has been shown to be involved in promoting colorectal carcinogenesis.
物理的形状
0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。
保管および安定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
M8445-BULK:
M8445-VAR:
IXO14206:
M8445-25UL:
M8445-200UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
David W Brammer et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(11), 2806-2811 (2018-03-02)
Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques (Macaca mulatta) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD Anderson Cancer
Y Wang et al.
Genes & development, 14(8), 927-939 (2000-04-27)
We report the identities of the members of a group of proteins that associate with BRCA1 to form a large complex that we have named BASC (BRCA1-associated genome surveillance complex). This complex includes tumor suppressors and DNA damage repair proteins
Xiaoqing Chen et al.
Nucleic acids research, 41(20), 9325-9338 (2013-08-14)
Exo1-mediated resection of DNA double-strand break ends generates 3' single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the
Association between MutL homolog 1 polymorphisms and the risk of colorectal cancer: a meta-analysis.
Haiyan Chen et al.
Journal of cancer research and clinical oncology, 141(12), 2147-2158 (2015-05-20)
As one of the most essential components of mismatch repair system, MutL homolog 1 (MLH1) plays an increasingly implicated role in initiation and promotion of colorectal carcinogenesis, with germ-line mutations in different loci. However, whether a single genetic variant in
Shinichiro Fukuhara et al.
Oncotarget, 5(22), 11297-11307 (2014-12-20)
Mismatch repair (MMR) enzymes have been shown to be deficient in prostate cancer (PCa). MMR can influence the regulation of tumor development in various cancers but their role on PCa has not been investigated. The aim of the present study
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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