L2420

モノクローナル抗LRP1抗体 マウス宿主抗体

~1.0 mg/mL, clone LRP1-11, purified immunoglobulin, buffered aqueous solution

• 別名: 抗A2MR抗体, 抗APOER抗体, 抗APR抗体, 抗CD91抗体, 抗LRP抗体, 抗アポリポタンパク質Eレセプター抗体, 抗アポリポタンパク質レセプター抗体, 抗リポタンパク質受容体関連タンパク質抗体, 抗低密度リポタンパク質受容体関連タンパク質1抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: LRP1-11, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~500 kDa
• 化学種の反応性: human, rat, mouse
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: suitable; western blot: 1-2 μg/mL
• アイソタイプ: IgG1
• UniProtアクセッション番号: Q07954
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LRP1(4035) ; mouse ... Lrp1(16971) , Lrp1(299858)

詳細

詳細

Monoclonal Anti-LRP1 (mouse IgG1 isotype) is derived from the hybridoma LRP1-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human LRP1, conjugated to KLH. LDL receptor family. Low-density lipoprotein (LDL) receptor related protein 1 (LRP1) gene is mapped to human chromosome 12q13.3. LRP1 protein, belongs to the LDL receptor family. LRP1, a single-chain 600 kDa type I transmembrane glycosylated precursor protein, is produced in the endoplasmic reticulum. This protein is proteolytically cleaved in the Golgi complex into two subunits including 85-kDa membrane-bound C-terminal membrane spanning subunit and a noncovalently attached 515-kDa N-terminal subunit.

特異性

Monoclonal Anti-LRP1 recognizes human, rat, and mouse LRP1.

アプリケーション

Monoclonal Anti-LRP1 antibody produced in mouse has been used in:

• immunoblotting
• enzyme linked immunosorbent assay
• immunofluorescence

生物化学的／生理学的作用

Low density lipoprotein receptor related protein 1 (LRP1) plays an essential role in early stages of embryonic development. It aids in lipoprotein metabolism, proteinase regulation, activation of lysosomal enzymes and cellular entry of viruses and toxins. Additionally, It is also implicated in cell signaling pathways, cell migration, and neurodevelopment. LRP1 interacts with at least 30 different ligands including lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. Furthermore, LDL receptor related protein 1 also has an ability to associate with bacterial toxins and viruses.

物理的形状

0.01M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

保管および安定性

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable