HPA021816

Anti-NUP88 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-88 kDa nuclear pore complex protein, Anti-Nuclear pore complex protein Nup88, Anti-Nucleoporin Nup88
• MDL番号: MFCD03455667
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA021816
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• テクニック: immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:20-1:50
• 免疫原配列: QLLTRNVVFGLGGELFLWDGEDSSFLVVRLRGPSGGGEEPALSQYQRLLCINPPLFEIYQVLLSPTQHHVALIGIKGLMVLELPKRWGKNSEFEGGKSTVNCSTTPVAERFFTSSTSLTLKHAAWYPSEILDPHVV
• UniProtアクセッション番号: Q99567
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NUP88(4927)

詳細

詳細

NUP88 (Nucleoporin 88kDa) is an 88kDa non-FG nucleoporin. It acts as a component of novel nuclear pore complex (NPC). It consists of a C-terminal coiled-coil domain and an interaction domain. It is localized in the cytoplasmic surface of nuclear pore complexes (NPCs). NUP88 consists of two domains, N-terminal and C-terminal domains and its N-terminal and C-terminal domains have been predicted to form β-propeller and a coiled-coil domain.

免疫原

Nup88核膜孔複合体タンパク質のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

NUP88 (Nucleoporin 88kDa) participates in trafficking between the nucleus and cytoplasm. Its N-terminal β-propeller domain interacts with the FG (phenylalanine-glycine) repeat domain of nucleoporin CAN/Nup214. Futher it binds directly to CRM-1/exportin-1, the receptor for export of most proteins from the nucleus. Nup88 also possesses the binding ability for the other FG nucleoporins Nup358 and Nup98. Overexpression of NUP88 has been observed in several types of malignancies such as colorectal cancer (CRC), breast cancer cells.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST75556

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable