HPA018499

Anti-USP4 antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-Deubiquitinating enzyme 4, Anti-Ubiquitin carboxyl-terminal hydrolase 4, Anti-Ubiquitin thioesterase 4, Anti-Ubiquitin-specific-processing protease 4, Anti-Ubiquitous nuclear protein homolog
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA018499
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:200-1:500
• 免疫原配列: NMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPL
• UniProtアクセッション番号: Q13107
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... USP4(7375)

詳細

詳細

The gene USP4 (ubiquitin carboxyl-terminal hydrolase-4) is mapped to human chromosome 3p21.3. The protein is present in the cytoplasm and the nucleus.

免疫原

ユビキチンC末端ヒドロラーゼ4のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

USP proteins are mainly responsible for deubiquitination of target proteins. Ubiquitin carboxyl-terminal hydrolase-4 (USP4) binds and deubiquitinates retinoic acid-inducible gene 1 (RIG1), thereby positively regulating RIG1-mediated antiviral response. USP4 deubiquitinates TRAF6 (TNF receptor-associated factor 6) and prevents the activation of NF (Nuclear factor)-κB and AP-1 (Activator protein-1) transcription factors, and subsequent innate immune activation. USP4 mRNA is elevated in small cell tumors and adenocarcinomas of the lung. USP4 is up-regulated in head and neck squamous cell carcinoma (HNSCC) and promotes tumor necrosis factor-α-induced apoptosis in HNSCC.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST86202

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable