HPA013547

Anti-CYP2C8 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-CYPIIC8, Anti-Cytochrome P450 2C8, Anti-P450 IIC2, Anti-P450 MP- 12/MP-20, Anti-P450 form 1, Anti-S-mephenytoin 4-hydroxylase
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA013547
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• 強化検証: orthogonal RNAseq; independent; Learn more about Antibody Enhanced Validation
• テクニック: immunohistochemistry: 1:20-1:50; western blot: 0.04-0.4 μg/mL
• 免疫原配列: KRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
• UniProtアクセッション番号: P10632
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CYP2C8(1558)

詳細

詳細

CYP2C8 (cytochrome P450, family 2, subfamily C, polypeptide 8) has been found to be expressed in the kidney, adrenal gland, brain, uterus, mammary gland, ovary, and duodenum. The gene is mapped to human chromosome 10q23.

免疫原

チトクロムP450 2C8のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

CYP2C8 (cytochrome P450, family 2, subfamily C, polypeptide 8) gene encodes a protein belonging to the cytochrome P450 superfamily of enzymes that function as monooxygenases. It is the major enzyme in the liver and kidney that is involved in the metabolism of arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). EETs function in several processes such as, peptide hormone secretion in the pancreas and pituitary, Na⁺ transport and water reabsorption in the kidney, platelet aggregation, etc. It is also the primary enzyme functioning in the metabolism of anticancer drug paclitaxel. It can also metabolize precarcinogen benzo(α)pyrene in humans and may have a role in carcinogenesis. It is found to act on other drugs such as, roziglitazone, a drug used in patients with adult onset of diabetes. It also mediates the maintenance of vascular tone in coronary arteries.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST72891

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)