H9666

NGF-β ヒト

NGF-β, recombinant, expressed in HEK 293 cells, HumanKine^™, suitable for cell culture

• 別名: NGF-β human
• MDL番号: MFCD00164982
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in HEK 293 cells
• アッセイ: ≥95% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: ≤16 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: 13 kDa (non-glycosylated)
• 包装: pkg of 10 μg
• メーカー／製品名: HumanZyme
• テクニック: cell culture | mammalian: suitable
• 不純物: ≤1 EU/μg
• 保管温度: −20°C

詳細

詳細

HumanKine NGF-β is expressed in human 293 cells as a non-glycosylated, non-disulfide bonded 13 kDa homodimer.

NGF-β belongs to the nerve growth factor protein superfamily. It is a key growth factor in target-mediated regulation of peripheral innervation. During development, NGF-β regulates nerve cell death, synaptic connectivity, fiber guidance, and dendritic morphology. The presence of NGF-β in immune cells and endocrine cells as well as in the CNS limbic areas suggests that it may function as an intracellular messenger to regulate the body′s response to stress.

The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.

アプリケーション

Nerve Growth Factor β Human has been used as a neurotrophic agent in luciferase reporter assay using mammalian cells.

生物化学的／生理学的作用

Nerve Growth Factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFB is known to promote cancer cell proliferation and metastasis. It is associated with lung, breast, prostatic and pancreatic cancers. In animal models, NGFB is observed to prevent cholinergic neuron loss and enhances memory.

物理的形状

Lyophilized from a 0.2 μm filtered solution of 1X PBS

アナリシスノート

The specific activity was determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells (human erythroleukemic indicator cell line).

法的情報

3D Insert is a trademark of 3D Biotek, LLC

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable