由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~24 kDa
交差性
human
濃度
~1.0 mg/mL
テクニック
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXB7
indirect immunofluorescence: 1-2 μg/mL using using paraformaldehyde fixed HEK-293T cells over expressing human HOXB7
western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXB7
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... HOXB7(3217)
mouse ... Hoxb7(15415)
詳細
Homeobox B7 (HOXB7) gene is mapped to human chromosome 17q21.32. In vertebrates, 39 HOX genes are organized into four clusters (HOXA-HOXD), located on different chromosomes (7p15, 17q21.2, 12q13, and 2q31). HOX proteins have a highly conserved 60-amino-acid region (the homeobox).
特異性
Anti-HOXB7 (C-terminal) recognizes human HOXB7 (also known as HOX2; HOX2C; HHO.
アプリケーション
Anti-HOXB7 (C-terminal) antibody produced in rabbit may be used in immunoblotting.
生物化学的／生理学的作用
The homeobox with DNA-binding activity, contributes to their activity as transcription factors. Hox genes are evolutionarily conserved transcription factors, which act to control important development pathways involved in the morphogenesis of the embryo. HOXB7 is expressed in various human hematopoietic cell lines and tissues as well as in proliferating melanocytes. In addition to roles in normal development, altered homeobox gene function or expression is implicated in carcinomas associated with breast, prostate, kidney, colon, skin and brain.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
IXO14814:
H0541-200UL:
H0541-VAR:
H0541-BULK:
H0541-25UL:
最新バージョンのいずれかを選択してください：
Dong Gao et al.
American journal of physiology. Cell physiology, 315(5), C675-C686 (2018-08-02)
Metastatic cutaneous squamous cell carcinoma (CSCC) is a major cause of death associated with nonmelanoma skin cancer. The involvement of homeobox B7 ( HOXB7) in cancers has been reported. Thus, the current study intends to explore the effect of HOXB7
Elisabetta Manuela Foppiani et al.
Stem cell research & therapy, 10(1), 101-101 (2019-03-21)
The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing
Yang Yang et al.
Molecular medicine reports, 16(3), 2773-2778 (2017-07-06)
Osteosarcoma is the most common primary malignant bone cancer in children and adolescents. Unfortunately, treatment failures are common due to metastasis and chemore-sistance, however, the underlying molecular mechanism remains unclear. Accumulating evidence indicated that the homeobox B7 (HOXB7) gene was
M T Lewis
Breast cancer research : BCR, 2(3), 158-169 (2001-03-16)
Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic
Nobumoto Tomioka et al.
Cancer genetics and cytogenetics, 201(1), 6-14 (2010-07-17)
Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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