G8044

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• MDL番号: MFCD06798487
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 46 kDa
• 化学種の反応性: mouse
• 包装: pkg of (1 vl = 100ul)
• テクニック: western blot: 1:500
• UniProtアクセッション番号: Q08369
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... GATA4(2626) ; mouse ... Gata4(14463) ; rat ... Gata4(54254)

詳細

免疫原

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.

synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

生物化学的／生理学的作用

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser¹⁰⁵ of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

物理的形状

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids