由来生物
rabbit
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human kidney, cortex
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... FZD10(11211)
mouse ... Fzd10(93897)
免疫原
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-10, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.
アプリケーション
Anti-Frizzled-10 antibody is suitable for immunohistochemistry study (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human kidney, cortex.
生物化学的／生理学的作用
Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In humans, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD10, a cell-surface receptor molecules in the Wnt pathway, is expressed during development in embryonic limbs, neural tube, and central nervous system and mediates Wnt signaling. It was reported that FZD10 plays a critical role in the metastasis of synovial sarcoma. Mechanistically, it facilitates the activation of Dvl-Rac1-JNK axis of planar cell polarity (PCP) signaling, with no effect on nuclear β-catenin accumulation and Tcf/Lef reporter activity.
物理的形状
PBS溶液(pH 7.7, 0.01%アジ化ナトリウム含有)。
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最新バージョンのいずれかを選択してください：
Yingqun Wang
Molecular cancer therapeutics, 8(8), 2103-2109 (2009-08-13)
The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/beta-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar
Satoshi Nagayama et al.
Oncogene, 24(41), 6201-6212 (2005-07-12)
Genome-wide expression profiling revealed overexpression of the gene encoding frizzled homologue 10 (FZD 10), a cell-surface receptor for molecules in the Wnt pathway, as a potential contributor to synovial sarcomas (SS). Northern blotting and immunohistochemical staining confirmed that expression levels
Edlaine Linares et al.
Chemical research in toxicology, 37(7), 1129-1138 (2024-06-25)
Peroxymonocarbonate (HCO4-/HOOCO2-) is produced by the reversible reaction of CO2/HCO3- with H2O2 (K = 0.33 M-1, pH 7.0). Although produced in low yields at physiological pHs and H2O2 and CO2/HCO3- concentrations, HCO4- oxidizes most nucleophiles with rate constants 10 to
H Kirikoshi et al.
International journal of oncology, 19(4), 767-771 (2001-09-20)
Frizzled (FZD) genes encode seven-transmembrane type WNT receptors, which are implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, and FZD10. Here, we investigated expression profiles of all members of
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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