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F0287

フィブロネクチン

Name: フィブロネクチン
Brand: SIGMA

lyophilized powder, 70 kDa

別名:

Fibronectin

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この商品について

UNSPSC Code:

12352202

eCl@ss:

42020141

NACRES:

NA.75

MDL number:

MFCD00131062

Form:

lyophilized powder

Assay:

>90% (SDS-PAGE)

Biological source:

human plasma

Mol wt:

70 kDa

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特性

biological source

human plasma

Quality Segment

200

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

70 kDa

packaging

pkg of 0.5 mg

technique(s)

cell culture | mammalian: suitable

impurities

HIV and HBsAg, source material tested negative, Small proteolytic fragments, may contain traces

solubility

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

UniProt accession no.

P02751

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... FN1(2335)

詳細

General description

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Application

Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

Biochem/physiol Actions

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis.[1] Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Preparation Note

70 kDaのこのN末端断片は、カテプシンDの消化により得られます。

Disclaimer

凍結乾燥品(PBS, 凍結保護剤としてスクロ-ス含有)

類似品目との比較

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当該品目	F0895	F2006	10838039001
Sigma-Aldrich F0287 フィブロネクチン	Sigma-Aldrich F0895 ヒト血漿由来フィブロネクチン	Sigma-Aldrich F2006 ヒト血漿フィブロネクチン	Roche 10838039001 フィブロネクチン
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay >90% (SDS-PAGE)	assay -	assay ≥85% (SDS-PAGE)	assay 95% (SDS-PAGE)
biological source human plasma	biological source human plasma	biological source human plasma	biological source human plasma
mol wt 70 kDa	mol wt -	mol wt 450 kDa	mol wt 440 kDa
form lyophilized powder	form liquid	form lyophilized powder	form lyophilized (clear, colorless solution after reconstitution)
shipped in ambient	shipped in wet ice	shipped in dry ice	shipped in -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c