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EHU012921

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human ABCG2

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About This Item

UNSPSCコード:

41105324

NACRES:

NA.51

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N1377

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487506

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EHU123221

MISSION^® esiRNA

詳細

品質水準

100

製品種目

MISSION^®

フォーム

lyophilized powder

esiRNA cDNA標的配列

TTATCCGTGGTGTGTCTGGAGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTGTTCTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCAAATGCTGTCCTTTTGCTCCTGAAAAGGATGTCTAAGCAGGGACGAACAATCATCTTCTCCATTCATCAGCCTCGATATTCCATCTTCAAGTTGTTTGATAGCCTCACCTTATTGGCCTCAGGAAGACTTATGTTCCACGGGCCTGCTCAGGAGGCCTTGGGATACTTTGAATCAGCTGGTTATCACTGTGAGGCCTATAATAACCCTGCAGACTTCTTCTTGGACATCATTAATGGAGATTCCACTGCTGTGGCATTAAACAGAGAAGAAGACTTTAAAGCCACAGAGATCATAGAGCCTTCCAAGCAGG

Ensembl |ヒトアクセッション番号

ENSG00000118777

NCBIアクセッション番号

NM_004827

輸送温度

ambient

保管温度

−20°C

遺伝子情報

human ... ABCG2(9429) , ABCG2(9429)

詳細

MISSION^® esiRNAは、エンドリボヌクレアーゼで調製されたsiRNAです。同じmRNA配列を標的とするsiRNAの不均質混合物です。これらの複数のサイレンシングトリガーにより、高度に特異的で効率的な遺伝子抑制が行われます。

追加情報については、またesiRNAのオプションすべてを表示するには、SigmaAldrich.com/esiRNAにアクセスしてください。

法的情報

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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ABCG2 downregulation in glioma stem cells enhances the therapeutic efficacy of demethoxycurcumin.

Long Chen et al.

Oncotarget, 8(26), 43237-43247 (2017-06-08)

We analyzed the role of ABCG2, a drug transporter, in determining the sensitivity of glioma stem cells (GSCs) to demethoxycurcumin (DMC). We first demonstrated that ABCG2 is more highly expressed in GSCs than primary astrocytes. Modulation of ABCG2 levels in

Inhibition of ABCG2 efflux pumps renders the Mycobacterium tuberculosis hiding in mesenchymal stem cells responsive to antibiotic treatment.

Simran Kaur et al.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 87, 104662-104662 (2020-12-06)

The lengthy TB chemotherapeutic regimen, resulting in the emergence of drug resistance strains, poses a serious problem in the cure of the disease. Further, one-quarter of the world's population is infected with dormant M.tb, which creates a lifetime risk of

Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.

Hisakazu Komori et al.

Biochimica et biophysica acta, 1860(5), 973-980 (2018-01-11)

Hyperuricemia has been recognized as an independent risk factor for cardiovascular disease. Urate stimulates NADPH oxidase and induces production of reactive oxygen species (ROS); consequently, intracellular urate accumulation can induce oxidative stress leading to endothelial dysfunction. Here, we studied the

ABCG2 confers promotion in gastric cancer through modulating downstream CRKL in vitro combining with biostatistics mining.

Junqing Wang et al.

Oncotarget, 8(3), 5256-5267 (2016-12-29)

ABCG2, member of ATP-binding cassette (ABC) transporter family, is known as crucial regulator related to multi-drug resistance in human tumors and has recently been putatively studied as human carcinoma cell biomarker. While, effects of ABCG2 on human gastric cancer (GC)

Nobiletin exhibits potent inhibition on tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via targeting ABCG2 and AKR1B1.

Kang Xu et al.

Phytotherapy research : PTR, 33(6), 1717-1725 (2019-04-25)

Inflammation is considered to be one of the initial critical factors in the occurrence of calcific heart valve disease. This study was to prove Nobiletin (NBT) inhibits inflammation-caused calcification of human valve interstitial cells (hVICs) and to elucidate the involved

主要文書

MISSION^® esiRNA