D8446
P7C3
≥98% (HPLC)
別名:
3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
5 mg | カートの在庫状況を確認する | ￥25,600 |
25 mg | カートの在庫状況を確認する | ￥92,600 |
この商品について
実験式（ヒル表記法）:
C21H18Br2N2O
CAS番号:
分子量:
474.19
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: 34 mg/mL
storage temp.
2-8°C
SMILES string
OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
InChI
1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
InChI key
FZHHRERIIVOATI-UHFFFAOYSA-N
Application
P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus.[1] P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.[2]
Biochem/physiol Actions
P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.
P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.
Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
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当該品目 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp |
| solubility DMSO: 34 mg/mL | solubility DMSO: ≥30 mg/mL | solubility DMSO: >10 mg/mL | solubility DMSO: 5 mg/mL, clear (warmed) |
| color white to off-white | color yellow | color yellow to orange | color white to beige |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable