D6446

DOV 216,303

≥98% (HPLC)

• 別名: (±)-1-(3,4-ジクロロフェニル)-3-アザビシクロ-[3.1.0]ヘキサン 塩酸塩
• 実験式（ヒル表記法）: C₁₁H₁₁Cl₂N · HCl
• CAS番号: 86215-36-3
• 分子量: 264.58
• NACRES: NA.77
• PubChem Substance ID: 329798827
• UNSPSC Code: 12352200
• MDL number: MFCD06407666
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

特性

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥10 mg/mL
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: −20°C
• SMILES string: Cl.Clc1ccc(cc1Cl)C23CNCC2C3
• InChI: 1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H
• InChI key: KAGBHVBIOJBGBD-UHFFFAOYSA-N

詳細

Biochem/physiol Actions

セロトニン・ノルエピネフリン・ドーパミン再取り込み阻害剤です。

トリプル再取り込み阻害剤(TRI)あるいはセロトニン・ノルエピネフリン・ドーパミン再取り込み阻害剤(SNDRI)です。それぞれに対するIC50値は、約20 nM、14 nM、78 nMです。

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P301 + P310 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• 保管分類: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable