C6344

モノクロナール抗コネクシン-32 マウス宿主抗体

clone CXN-32, ascites fluid, buffered aqueous solution

• MDL番号: MFCD00803531
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: primary antibodies
• クローン: CXN-32, monoclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 27 kDa
• 含みます: 15 mM sodium azide
• 交差性: human, rat, mouse
• テクニック: immunohistochemistry (frozen sections): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 1:1,000 using a mouse whole brain extract
• アイソタイプ: IgG1
• UniProtアクセッション番号: P08034
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GJB1(2705) , GJB2(2706) ; mouse ... Gjb1(14618) ; rat ... Gja1(24392) , Gjb1(29584)

詳細

詳細

Monoclonal Anti-Connexin-32 (mouse IgG1 isotype) is derived from the CXN-32 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The 27 kDa connexin protein (Connexin-32, Cx32), belongs to the connexion family of proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types including peripheral and central nervous system.

免疫原

合成コネキシン-32ペプチド(アミノ酸105-123)。

アプリケーション

Monoclonal Anti-Connexin-32 antibody produced in mouse has been used in:

• enzyme linked immunosorbent assay (ELISA)
• immunoblotting
• epifuorescent microscopy

生物化学的／生理学的作用

Connexin-32 low expression levels is observed in common bile duct ligation (CBDL). In addition, a combination of myelin disruption and axonal degeneration has been shown to occur with Cx32 mutations in Charcot-Marie-Tooth disease (CMTX). Monoclonal antibodies reacting specifically with Cx32, may be used in diverse cellular and molecular approaches to the study of gap junctions and their properties, and to correlate their expression pattern with physiological functions or pathological conditions.

Connexins belong to the gap junction protein family. In humans, connexin is encoded by GJB1 (gap junction protein, β 1) gene. The gap junction proteins connexin32 (Cx32), Cx37, Cx40 and Cx43 are expressed in endothelial cells and regulate vascular functions involving inflammation. The endothelial Cx32 positively regulates angiogenesis by enhancing endothelial cell tube formation and cell migration. CX32 mutation is associated with cognitive impairment and a differential degree of peripheral nerve involvement.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable