B6684

Rp-8-Bromo-β-phenyl-1,N²-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

≥98% (HPLC), powder

• 別名: Rp-β-Phenyl-1,N²-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt, Rp-8-Br-PET-cGMPS
• 実験式（ヒル表記法）: C₁₈H₁₄BrN₅NaO₆PS
• CAS番号: 185246-32-6
• 分子量: 562.27
• UNSPSCコード: 41106305
• PubChem Substance ID: 24724424
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 有効性: 30 nM K_i
• 色: white to beige
• mp: 240-300 °C (lit.)
• 溶解性: H₂O: 15 mg/mL at ≤60 °C
• 保管温度: −20°C
• SMILES記法: O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
• InChI: 1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
• InChI Key: SVMPQLHYWRTQCX-DBHVCDLJSA-M

詳細

生物化学的／生理学的作用

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (K_i = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 micromoles).

特徴および利点

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法的情報

U.S. Patent 5,625,056, DE Patent 4,217,679.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)