B1061

BN82002 hydrochloride

≥97% (HPLC), solid

• 別名: 4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol
• 実験式（ヒル表記法）: C₁₉H₂₅N₃O₄ · xHCl
• CAS番号: 396073-89-5
• 分子量: 359.42 (free base basis)
• MDL番号: MFCD08276984
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724410

特性

• アッセイ: ≥97% (HPLC)
• フォーム: solid
• 色: tan
• 溶解性: DMSO: 10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cl[H].COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C

詳細

生物化学的／生理学的作用

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor.

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC₅₀ in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC₅₀ in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

注意

Hygroscopic.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)