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リコンビナント
expressed in E. coli
形状
liquid
比活性
≥1 U/mL
保管温度
−20°C
アプリケーション
Adenosine deaminase (ADA) is a key enzyme in purine metabolism and is essential for normal immune function . It is important in the study of immune system diseases such as rheumatoid arthritis . Product 93985 is from human, is recombinant and is expressed in E. coli.
生物化学的／生理学的作用
Adenosine deaminase irreversibly deaminates adenosine to inosine. In addition to immune system regulation, ADA may be involved in epithelial cell differentiation, neurotransmission and gestation maintenance .
単位の定義
1 unitは、pH 7.5、25°C、1分間に、1.0 μmolのアデノシンをイノシンに脱アミノ化する酵素量です。
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
93985-BULK:
93985-VAR:
93985-5ML:
93985-1ML:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
H Yuksel et al.
Annals of the rheumatic diseases, 47(6), 492-495 (1988-06-01)
Adenosine deaminase activity was determined in paired samples of serum and synovial fluid taken from patients with rheumatoid arthritis (n = 12), reactive arthritis (n = 13), and osteoarthritis (n = 7), and the value of this investigation in the
D K Wilson et al.
Science (New York, N.Y.), 252(5010), 1278-1284 (1991-05-31)
The crystal structure of a murine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine ribonucleoside, a nearly ideal transition-state analog, has been determined and refined at 2.4 angstrom resolution. The structure is folded as an eight-stranded parallel alpha/beta barrel with a deep pocket
Rekha Dhanwani et al.
Science advances, 6(30), eaba3688-eaba3688 (2020-08-04)
Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood. Here, we identify a previously unidentified immune-metabolic axis by which cells respond to purine nucleosides and trigger a type
Yeon-Mi Lee et al.
Biophysical chemistry, 172, 18-25 (2013-01-22)
Human ADAR1, which has two left-handed Z-DNA binding domains, preferentially binds Z-DNA rather than B-DNA with a high binding affinity. Z-DNA can be induced in long genomic DNA by Z-DNA binding proteins through the formation of two B-Z junctions with
George R Thompson et al.
Chest, 143(3), 776-781 (2012-11-29)
In a patient with positive serum serology for coccidioidomycosis, the differential diagnosis of concurrent pleural effusions can be challenging. We, therefore, sought to clarify the performance characteristics of biochemical, serologic, and nucleic-acid-based testing in an attempt to avoid invasive procedures.
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