Glucose tetrasaccharide (Glc4) is used as a reference in analysis of urinary glucose tetrasacchaide, a biomarker for Pompe disease and other glycogen storage diseases.
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その他情報
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Journal of neuroimmunology, 217(1-2), 95-101 (2009-11-03)
The serum level of IgM antibodies against Glc(alpha1,4)Glc(alpha) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HC). Detecting the level of anti-GAGA4 antibody by enzyme immunoassay and total IgM
Genetics in medicine : official journal of the American College of Medical Genetics, 21(4), 887-895 (2018-09-15)
To investigate immune tolerance induction with transient low-dose methotrexate (TLD-MTX) initiated with recombinant human acid α-glucosidase (rhGAA), in treatment-naïve cross-reactive immunologic material (CRIM)-positive infantile-onset Pompe disease (IOPD) patients. Newly diagnosed IOPD patients received subcutaneous or oral 0.4 mg/kg TLD-MTX for 3
Molecular genetics and metabolism, 85(4), 247-254 (2005-05-12)
A tetraglucose oligomer, Glcalpha1-6Glcalpha1-4Glcalpha1-4Glc, designated Glc4, has been shown to be a putative biomarker for the diagnosis of Pompe disease. The purpose of this study was to assess whether Glc4 could be used to monitor the therapeutic response to recombinant
Journal of immunological methods, 68(1-2), 217-226 (1984-03-30)
Monoclonal antibodies were produced in BALB/cJ mice against a urinary glucose-containing tetrasaccharide (Glc)4 coupled to keyhole limpet hemocyanin (KLH). The immune response was studied using 7 different strains of mice and 11 different immunization protocols. From 6 fusions using the
Journal of inherited metabolic disease, 35(2), 311-316 (2011-06-21)
A high performance liquid chromatography method, adapted from an established urinary sugars method, has been developed for the analysis of a tetraglucose oligomer (Glc(4)) in urine. Pompe disease results from defects in the activity of lysosomal acid α-glucosidase (GAA) with
